GW7647 – CAS 265129-71-3 – Calbiochem

Descrição detalhada : A cell-permeable urea-substituted thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective PPARalpha agonist (PPARalpha, gamma and delta - EC50 = 6 nM, 1.1 µM and 6.2 µM for human; 1 nM, 1.3 µM and 2.9 µM for murine, respectively). Also displays in vivo lipid-lowering activity in rats., A cell-permeable, urea-substituted, thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonist (EC50 = 6 nM for human PPARalpha, 1.1 µM for human PPARgamma, and 6.2 µM human PPARdelta; 1 nM for murine PPARalpha, 1.3 µM for murine PPARgamma, and 2.9 µM murine PPARdelta). Also shown to lower lipid levels in rats.
Sinónimos : GW7647 - CAS 265129-71-3 - Calbiochem; GW647, 2-(4-(2-(1-Cyclohexanebutyl-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic Acid, PPAR Agonist IV, PPARalpha Agonist II, PPARbeta/delta Agonist I, PPARgamma Agonist III
Fórmula molecula r: C29H46N2O3S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG