HDL Receptor SR-BI Inhibitor, BLT-1 – CAS 321673-30-7 – Calbiochem

REF : 373210-25MG
Marca : Sigma-Aldrich
Descrição :HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem The HDL Receptor SR-BI Inhibitor, BLT-1, also referenced under CAS 321673-30-7, controls the biological activity of HDL Receptor SR-B. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable thiosemicarbazone copper chelator that potently blocks the HDL receptor SR-BI- (scavenger receptor, class B, type I) mediated lipid uptake (IC50 = 21 and 57 nM against DiI and CE uptake, respectively, from DiI-HDL and CE-HDL using hamster ldlA-7 cells expressing murine SR-BI) in a reversible manner, while exerting little effect toward intracellular membrane trafficking or cytoskeletal organization. BLT-1 chelates Cu+2 in a 2:1 stoichiometric ratio and a half molar equivalent of CuCl2 is shown to fully prevent zebrafish embryos from BLT-1-induced development defects, while BLT-1 can likewise be used to chelate excess amount of copper (>4 µM) and rescue embryos from copper toxicity.
Sinónimos : HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem; Block Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20
Fórmula molecula r: C12H23N3S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG