HIF-Hydroxylase Inhibitor, DMOG – CAS 89464-63-1 – Calbiochem

Descrição detalhada : A cell-permeable 2-OG (2-oxoglutarate) analog that is expected to act as a competitive inhibitor against all 2-OG-dependent dioxygenases. Effectively upregulates normoxia HIF-alpha transcription activity (effective conc. = 1 mM in cultures) by inhibiting HIF-PH- (HIF-alpha-prolyl hydroxylase) catalyzed ODD (oxygen-dependent degradation domain) Prolyl hydroxylation (Pro564 and Pro530 in HIF-1alpha and HIF-2alpha, respectively) and aspartyl/asparanginyl beta-hydroxylase-catalyzed CAD Asp hydroxylation (Asn803 and Asn851 in HIF-1alpha and HIF-2alpha, respectively), resulting in a blockage of pVHL (von Hippel-Lindau) ubiquitin ligase complex-mediated HIF-alpha degradation and a simultaneous promotion of HIF CAD (COOH-terminal activation domain) p300/CBP association. DMOG is also demonstrated to augment artery ligation-induced up-regulation of HIF-1alpha and FLK (by 100% and 40%, respectively, in 11 days; 8 mg/0.5 ml/animal/i.p.; q.o.d.) in muscle tissues in a murine ischaemic model in vivo.
Sinónimos : HIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1 - Calbiochem; N-(Methoxyoxoacetyl)-glycine methyl ester, Dimethyloxalylglycine, HIF Prolyl Hydroxylase Inhibitor I, HIF Aspartyl beta-Hydroxylase Inhibitor, HIF Asparanginyl beta-Hydroxylase Inhibitor
Fórmula molecula r: C6H9NO5
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X50MG