Histone Deacetylase Inhibitor II – CAS 174664-65-4 – Calbiochem

Descrição detalhada : A cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 µM). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma cells, which can be blocked by Caspase Inhibitor Z-VAD-FMK (Cat. No. 627610)., A cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 µM). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma.
Sinónimos : Histone Deacetylase Inhibitor II - CAS 174664-65-4 - Calbiochem; CBHA, m-Carboxycinnamic Acid bis-Hydroxamide; CBHA, m-Carboxycinnamic Acid bis-Hydroxamide
Fórmula molecula r: C10H10N2O4
Armazenamento : -20C
Embalagem : 1X5MG