(+/-)-Ibuprofen – CAS 15687-27-1 – Calbiochem

Descrição detalhada : A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC50 = 4.85 µM). Inhibits COX-2 at higher concentrations (IC50 = 223 µM). Blocks aspirin inactivation of COX-1 (EC50 antagonism of 200 µM aspirin = 290 nM). Shown to reduce the total Abeta secretion (Amyloid beta40 and 42) in human neuronal cells and offers neuroprotection against glutamate-, nitric oxide-, and superoxide-induced damage. Reported to activate peroxisome proliferator-activated receptors (PPAR) alpha and gamma in both CV-1 and C3H10T1/2 cells (~100 µM-500 µM)., A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible, competitive, non-selective cyclooxygenase (COX) inhibitor (IC50 = 4.85 µM for purified COX-1 and 223 µM for purified COX-2). Also reported to inhibit COX-1 and COX-2 activity in intact bovine aortic endothelial cells (BAEC) (IC50 = 7 µM for COX-1 and 72.7 µM for COX-2). Potently blocks aspirin inactivation of COX-1 (EC50 antagonism of 200 µM aspirin ~290 nM for ovine COX-1). Decreases the secretion of total Abeta (Amyloid beta40&42) by human neuronal cells and offers neuroprotection against glutamate-, nitric oxide- and superoxide-induced damage. Activates peroxisome proliferator activated receptors alpha and gamma in both CV-1 and C3H10T1/2 cells (~100 µM - 500 µM).
Sinónimos : (+/-)-Ibuprofen - CAS 15687-27-1 - Calbiochem; [(+/-)-2-(4-Isobutylphenyl)-propionic Acid
Fórmula molecula r: C13H18O2
Armazenamento : 10-30C
Embalagem : 1X1GM