IKK-2 Inhibitor V – CAS 978-62-1 – Calbiochem

REF : 401482-5MG
Marca : Sigma-Aldrich
Descrição :IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
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Descrição detalhada : A cell-permeable IKK-2 inhibitor that selectively blocks IkappaBalpha phosphorylation (IC50 ~250 nM) and prevents the induction of NF-kappaB p65 nuclear translocation. Reported to suppress neoplastic proliferation of mast cells with constitutively activated c-kit receptor. Shown to offer cardioprotection by reducing IL-1beta and MCP-1 production (IC50<1 µM) in cardiomyocytes, and ameliorate insulin resistance in diabetic KKAy mice by regulating adiponectin release., A cell-permeable salicylamide compound that acts as an IKK-2 inhibitor by selectively blocking IkappaBalpha phosphorylation (IC50 ~ 250 nM) and thereby prevents the induction of NF-kappaB p65 nuclear translocation. Shown to offer cardioprotection by reducing IL-1beta and MCP-1 production (IC50<1 µM) in cardiomyocytes, and ameliorate insulin resistance in KKAy mice by regulating adiponectin release.
Sinónimos : IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem; N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354
Fórmula molecula r: C15H8ClF6NO2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG