IKK Inhibitor VII – CAS 873225-46-8 – Calbiochem

Descrição detalhada : A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IkappaBalpha degradation and NF-kappaB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats., A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IkappaBalpha degradation and NF-kappaB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats. Also available as a 10 mM solution in DMSO (Cat. No. 505378).
Sinónimos : IKK Inhibitor VII - CAS 873225-46-8 - Calbiochem; IKK 16
Fórmula molecula r: C28H29N5OS
Armazenamento : -20C
Embalagem : 1X1MG