IKKgamma

Descrição detalhada : IKKgamma has been shown to play a critical role in NF-kappaB activation, as the regulatory subunit of IkappaB kinase, which phosphorylates inhibitors of NF-kappaB leading to their degradation. Upon cell stimulation, IKKgamma can be modified by Lys-63-linked or linear polyubiquitination, both of which are suggested to play key roles in cell signalling, including NF-kappaB activation. One of the E3 ligases responsible for Lys-63-linked IKKgamma polyubiquitination is TRAF6, which participates in several signalling pathways controlling immunity, skin development, osteoclast formation and brain functions.
Sinónimos : NF-kappa-B essential modulator. Inhibitor of nuclear factor kappa-B kinase subunit gamma, FIP-3, NEMO, IKKg
Armazenamento : -80°C
Embalagem : 1X1EA