Indirubin-3ʹ-monoxime-5-sulphonic Acid – CAS 331467-05-1 – Calbiochem

REF : 402088-1MG
Marca : Sigma-Aldrich
Descrição :Indirubin-3?-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem A potent, reversible, and selective inhibitor of Cdk1 (IC?? = 5 nM) and Cdk5 (IC?? = 7 nM) and glycogen synthase kinase-3beta (GSK-3beta; IC?? = 80 nM).
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Descrição detalhada : A highly potent, reversible, and selective inhibitor of cyclin-dependent kinases 1 and 5 (IC50 = 5 nM for CDK1; IC50 = 7 nM for CDK5). Reported to act by competing with ATP for binding to the catalytic site of the kinase. Also acts as a potent inhibitor of glycogen synthase kinase-3beta (GSK-3beta; IC50 = 80 nM)., A potent, reversible, and selective inhibitor of Cdk1 (IC50 = 5 nM) and Cdk5 (IC50 = 7 nM) and glycogen synthase kinase-3beta (GSK-3beta; IC50 = 80 nM). The inhibition is competitive with respect to ATP.
Sinónimos : Indirubin-3?-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem
Fórmula molecula r: C16H11N3O5S
Armazenamento : -20C
Embalagem : 1X1MG