InSolution Akt Inhibitor X – CAS 925681-41-0 – Calbiochem

Descrição detalhada : A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 M), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2, the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound is also available.
Sinónimos : InSolution Akt Inhibitor X - CAS 925681-41-0 - Calbiochem; 10-(4?-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl; 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl, 10-(4?-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl
Fórmula molecula r: C20H25ClN2O · xHCl
Armazenamento : -70C
Embalagem : 1X2MG