InSolution ALLN – CAS 110044-82-1 – Calbiochem

Descrição detalhada : A 10 mM solution of ALLN (Cat. No. 208719) in anhydrous DMSO. Inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and proteasome (Ki = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IkB-alpha and IkB-beta by the ubiquitin-proteasome complex.
Sinónimos : InSolution ALLN - CAS 110044-82-1 - Calbiochem; Calpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V
Fórmula molecula r: C20H37N3O4
Armazenamento : -20C
Embalagem : 1X5MG