InSolution APT1 Inhibitor, palmostatin B – Calbiochem

Descrição detalhada : A cell-permeable, beta-lactone acyl protein thioesterase 1 (APT1) inhibitor (IC50 = 0.67 µM, in an enzymatic assay) that is shown to specifically block Ras depalmitoylation, without affecting Ras acylation, in MDCK cells, both in vitro and in vivo. It induces a marked redistribution of NRas to endomembranes (1 µM) without notable cytotoxicity, and is shown to elicit a loss of the precise steady-state localization of palmitoylated Ras proteins in the same cell line. At 50 µM, this inhibitor displays a partial phenotypic reversion in oncogenic HRasG12V-transformed fibroblasts. Furthermore, it demonstrates selectivity for APT1 over phospholipase A1, A2, Cbeta and D. It's inhibitory effect is demonstrated to be consistent with that of APT1 downregulation by siRNA.
Sinónimos : InSolution APT1 Inhibitor, palmostatin B - Calbiochem; APT1 Inhibitor
Fórmula molecula r: C23H36O4
Armazenamento : -70C
Embalagem : 1X1EA