InSolution BAY 11-7082 – Calbiochem

Descrição detalhada : Potential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFalpha-inducible phosphorylation of IkappaB-alpha (IC50 = 10 µM) without affecting the constitutive IkappaB-alpha phosphorylation. Decreases nuclear translocation of NFkappaB and inhibits TNFalpha-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50 ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.
Sinónimos : InSolution BAY 11-7082 - Calbiochem
Fórmula molecula r: C10H9NO2S
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG