InSolution Calyculin A, Discodermia calyx – CAS 101932-71-2 – Calbiochem

Descrição detalhada : Cell-permeable protein phosphatase 2A (PP2A) inhibitor (IC50 = 0.5-1.0 nM). Also inhibits protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Recently, it has been used to study the regulation of Ca2+-activated K+ channels in smooth muscle and to correlate shape changes in fibroblasts with the degree of protein phosphorylation. Also known to prevent gamma-radiation induced apoptosis in Burkitt's lymphoma cell line BM13674.
Sinónimos : InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
Fórmula molecula r: C50H81N4O15P
Armazenamento : -70C
Embalagem : 1X1EA