InSolution JAK Inhibitor I – CAS 457081-03-7 – Calbiochem
REF : 420097-500UG
Marca : Sigma-Aldrich
Descrição :InSolution JAK Inhibitor I - CAS 457081-03-7 - Calbiochem The InSolution JAK Inhibitor I, also referenced under CAS 457081-03-7, controls the biological activity of JAK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Categoria : Small Molecules
Descrição detalhada : A potent inhibitor of Janus Protein tyrosine Kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). It inhibits other kinases only at much higher concentrations. Also inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks the phosphorylation of STAT5.
Sinónimos : InSolution JAK Inhibitor I - CAS 457081-03-7 - Calbiochem; 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
Fórmula molecula r: C18H16FN3O
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X500UG
Sinónimos : InSolution JAK Inhibitor I - CAS 457081-03-7 - Calbiochem; 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
Fórmula molecula r: C18H16FN3O
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X500UG