InSolution MG-132 in EtOH, >=95% by HPLC – Calbiochem

Descrição detalhada : Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-kappaBactivation (IC50 = 3 µM). This material is >=95% pure by HPLC. A material with >=98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available., Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-kappaB activation (IC50 = 3 µM). This material is >=95% pure by HPLC. A material with >=98% purity by HPLC (Cat. No. 474791) is also available.
Sinónimos : InSolution MG-132 in EtOH, >=95% by HPLC - Calbiochem; Proteasome Inhibitor XI
Fórmula molecula r: C26H41N3O5
Armazenamento : -70C
Embalagem : 1X10MG