InSolution OM99-2 – CAS 314266-76-7 – Calbiochem

Descrição detalhada : An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (Ki = 1.6 nM, recombinant memapsin 2; Ki = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (Ki = 48 nM). This aspartyl protease inhibitor is designed from the template of the beta-secretase site of Swedish beta-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala., A peptidomimetic, highly potent, tight-binding transition-state analog inhibitor of human brain beta-secretase (Ki = 1.6 nM, recombinant memapsin-2; Ki = 9.58 nM, recombinant pro-memapsin 2). Designed from the template of the beta-secretase site of Swedish beta-amyloid precursor protein (APP) with Asp to Ala replacement. Includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala. Also reported to inhibit cathepsin D at higher levels (Ki = 48 nM).
Sinónimos : InSolution OM99-2 - CAS 314266-76-7 - Calbiochem; EVNLPsiAAEF
Fórmula molecula r: C41H64N8O14
Armazenamento : -20C
Embalagem : 1X250UG