InSolution PD 98059 – CAS 167869-21-8 – Calbiochem

Descrição detalhada : Selective and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase of MAP kinase activity produced by nerve growth factor (NGF; IC50 = 2 µM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the pp140trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Inhibits cell growth and reverses the phenotype of ras-transformed BALB 3T3 mouse fibroblasts and rat kidney cells.
Sinónimos : InSolution PD 98059 - CAS 167869-21-8 - Calbiochem; MEK Inhibitor V
Fórmula molecula r: C16H13NO3
Armazenamento : -20C
Embalagem : 1X1ML