InSolution Rapamycin – Calbiochem

REF : 553211-500UG
Marca : Sigma-Aldrich
Descrição :InSolution Rapamycin - Calbiochem InSolution Rapamycin, CAS 53123-88-9, is a 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO. Selectively inhibits mTOR and blocks activation of p70 S6 Kinase (IC?? = 50 pM).
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Descrição detalhada : Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
Sinónimos : InSolution Rapamycin - Calbiochem; mTOR Inhibitor I
Fórmula molecula r: C51H79NO13
Armazenamento : -20C
Embalagem : 1X500UG