InSolution TAPI-2 – CAS 187034-31-7 – Calbiochem

REF : 5096120001
Marca : Sigma-Aldrich
Descrição :InSolution™ TAPI-2 - CAS 187034-31-7 - Calbiochem A 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 in H?O.
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Descrição detalhada : A hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-alpha convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-alpha, IL-6 receptor alpha-subunit, and beta-amyloid precursor protein. Reported to inhibit TNF-alpha release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM).
Sinónimos : InSolution TAPI-2 - CAS 187034-31-7 - Calbiochem
Fórmula molecula r: C19H37N5O5
Armazenamento : -70C
Embalagem : 1X1EA