InSolution U0126 – CAS 109511-58-2 – Calbiochem

Descrição detalhada : A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.
Sinónimos : InSolution U0126 - CAS 109511-58-2 - Calbiochem
Fórmula molecula r: C18H16N6S2 · 0.5C2H6O
Armazenamento : -70C
Embalagem : 1X5MG