Integrin alphavbeta3 Antagonist, P11 – Calbiochem

Descrição detalhada : A cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin alphavbeta3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
Sinónimos : Integrin alphavbeta3 Antagonist, P11 - Calbiochem; HSDVHK-NH2, HSDVHK
Fórmula molecula r: C30H51N12O93 · 3C2HF3O2
Armazenamento : -20C
Embalagem : 1X5MG