Ionomycin, Free Acid, Streptomyces conglobatus – CAS 56092-81-0 – Calbiochem

Descrição detalhada : Highly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines., Absorption max. (280 nm, MeOH): 18,600 M-1cm-1., Highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.
Sinónimos : Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem
Fórmula molecula r: C41H72O9
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG