IQ-1 – CAS 331001-62-8 – Calbiochem

Descrição detalhada : A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished β-catenin/p300 interaction and a concomitant increase in β-catenin/CBP usage. Co-adminitration of IQ-1 (4 microg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum.
Sinónimos : IQ-1 - CAS 331001-62-8 - Calbiochem; 2-(4-Acetylphenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetamide, Wnt Pathway Activator III
Fórmula molecula r: C21H22N4O2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG