JAK2 Inhibitor II – CAS 1837-91-8 – Calbiochem

REF : 420132-25MG
Marca : Sigma-Aldrich
Descrição :JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem The JAK2 Inhibitor II, also referenced under CAS 1837-91-8, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in gamma2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts., A cell-permeable, specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2 that interacts with a solvent-accessible pocket near the activation loop of JAK2. Reduces growth hormone-mediated JAK2 activation in gamma2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
Sinónimos : JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem; 1,2,3,4,5,6-Hexabromocyclohexane
Fórmula molecula r: C6H6Br6
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG