JNK Inhibitor V – CAS 345987-15-7 – Calbiochem

REF : 420129-5MG
Marca : Sigma-Aldrich
Descrição :JNK Inhibitor V - CAS 345987-15-7 - Calbiochem The JNK Inhibitor V, also referenced under CAS 345987-15-7, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.
Sinónimos : JNK Inhibitor V - CAS 345987-15-7 - Calbiochem; SAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
Fórmula molecula r: C20H16N6S
Armazenamento : -20C
Embalagem : 1X5MG