Kaempferol – CAS 520-18-3 – Calbiochem

Descrição detalhada : A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Abeta25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Abeta-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC50 = 180 µM), and of transcriptional activation of COX-2 (IC50<15 µM)., A cell-permeable, phytoestrogen that offers protection against Abeta25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Reduces the activation of caspases 2, 3, 8, and 9 by Abeta. Inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Also shown to protect against NMDA-induced neuronal toxicity in vitro in cultured rat cortical neurons. Acts as an inhibitor of cyclooxygenases (COX-1, IC50 = 180 µM) and COX-2 (IC50 = ~15 µM).
Sinónimos : Kaempferol - CAS 520-18-3 - Calbiochem; 3,4?,5,7-Tetrahydroxyflavone
Fórmula molecula r: C15H10O6
Armazenamento : -20C
Embalagem : 1X25MG