Lovastatin, Sodium Salt – Calbiochem

Descrição detalhada : Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays., Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
Sinónimos : Lovastatin, Sodium Salt - Calbiochem; L-Type Calcium Channel Blocker IV
Fórmula molecula r: C24H37O6 · Na
Armazenamento : -20C
Embalagem : 1X5MG