MARK/Par-1 Activity Inhibitor, 39621 – Calbiochem

Descrição detalhada : A cell-permeable dihydropyrazinyl-thioacetamide that acts as an ATP-competitive MARK inhibitor (IC50 = 3.6 microM; [ATP] = 100 microM) with much reduced or little activity against GSK-3β, SAD-kinase B/BRSK-1, MARKK/TAO-1, Cdc2/cycB, and p38/SAPK (30%, 20%, 11%, 4%, and 0% inhibition, respectively; [inhibitor] = 50 microM). Shown to effectively block primary rat cortical neuron axon growth (5.7 microm/hr vs 32.5 microm/hr with or without 20 microM inhibitor) and prevent MARK2 overexpression-induced Tau Ser262 phosphorylation and cytotoxicity due to microtubule network breakdown in CHO cells (10 microM)., A cell-permeable dihydropyrazinyl-thioacetamide that acts as an ATP-competitive MARK-selective inhibitor (IC50 = 3.6 microM; [ATP] = 100 microM). Shown to effectively block primary rat cortical neuron axon growth (5.7 microm/hr vs 32.5 microm/hr with or without 20 microM inhibitor) and prevent MARK2 overexpression-induced Tau Ser262 phosphorylation and cytotoxicity in CHO cells (10 microM).
Sinónimos : MARK/Par-1 Activity Inhibitor, 39621 - Calbiochem; Microtubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhibitor, N-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide; N-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide, Microtubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhibitor
Fórmula molecula r: C21H21N3O3S
Armazenamento : -20C
Embalagem : 1X10MG