Merbarone – CAS 97534-21-9 – Calbiochem

Descrição detalhada : A cell-permeable, anticancer drug that inhibits the catalytic activity of DNA topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 µM for purified mammalian topoisomerase II versus IC50 ~200 µM for topoisomerase I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism., A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 µM for purified mammalian topo II versus IC50 = ~ 200 µM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.
Sinónimos : Merbarone - CAS 97534-21-9 - Calbiochem; 5-(N-Phenylcarboxamido)-2-thiobarbituric Acid, NSC-336628
Fórmula molecula r: C11H9N3O3S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG