mGluR5 Antagonist, MTEP – CAS 329205-68-7 – Calbiochem

REF : 445874-5MG
Marca : Sigma-Aldrich
Descrição :mGluR5 Antagonist, MTEP - CAS 329205-68-7 - Calbiochem The mGluR5 Antagonist, MTEP, also referenced under CAS 329205-68-7, controls the biological activity of mGluR5. This small molecule/inhibitor is primarily used for Neuroscience applications.
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Descrição detalhada : A brain-permeable (thiazole-pyridine)alkyne compound that acts as a potent, selective and non-competitive mGluR5 (metabotropic glutamate receptor subtype-5) antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM) with in vivo anxiolytic activity in a rodent model (ED50 = 1 mg/kg, ip and 7 mg/kg, po). Devoid of any side effects seen with MPEP and benzodiazepines. Reported to weakly affect the activities of other enzymes and receptors tested (IC50 = 30 µM for MAO-A, >100 µM for mGlu1R, 2R & 7R, and >300 µM for NR2BR).
Sinónimos : mGluR5 Antagonist, MTEP - CAS 329205-68-7 - Calbiochem; 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine
Fórmula molecula r: C11H8N2S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG