MIF Antagonist V, p425 – CAS 259444 – Calbiochem

Descrição detalhada : A symmetrical bis-(amino, hydroxynaphthalenedisulfonate) compound that antagonizes macrophage migration inhibitory factor against receptor binding (IC = 810 nM against hMIF and CD74 interaction) and is more potent than ISO-1 (Cat. No. 475837) in suppressing MIF-induced cytokines and MMP-3 productions in human fibroblasts cultures (IC = ≤0.7 microM vs >5 microM). Unlike MIF Antagonists I-IV, p425 targets an area at the interface of two MIF trimers, distal to the active site., A symmetrical bis-(amino, hydroxynaphthalenedisulfonate) compound that antagonizes macrophage migration inhibitory factor against receptor binding (IC = 810 nM against hMIF and CD74 interaction) and is more potent than ISO-1 (Cat. No. 475837) in suppressing both MIF-induced IL-6 and IL-8 production in human foreskin fibroblasts (IC = 0.6 - 0.7 microM vs >5 microM) and MIF-induced MMP-3 production in human synovial fibroblasts (IC = 0.1 microM vs >10 microM). Shown to exhibit little cytotoxicity in human foreskin fibroblast cultures even at concentrations as high as 100 microM. Unlike MIF Antagonists I-IV, p425 targets an area at the interface of two MIF trimers, distal to the active site.
Sinónimos : MIF Antagonist V, p425 - CAS 259444 - Calbiochem; Sodium 6,6?-(1 E,1? E)-(3,3?-dimethoxybiphenyl-4,4?-diyl) bis(diazene-2,1-diyl) bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate); Sodium 6,6?-(1E,1?E)-(3,3?-dimethoxybiphenyl-4,4?-diyl)bis(diazene-2,1-diyl)bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate)
Fórmula molecula r: C34H24N6Na4O16S4
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X2GM