MILLIPLEX(R) RTK Phosphoprotein Magnetic Bead Panel- Cell Signaling Multiplex Assay

Descrição detalhada : RTKs (Receptor Tyrosine Kinases) are transmembrane proteins that act as receptors for growth factors, neurotrophic factors and other extracellular signaling molecules. Upon binding extracellular ligands, RTKs can undergo receptor dimerization and tyrosine phosphorylation on specific residues in the cytoplasmic tails which then lead to RTK-mediated signal transduction. Of the greater than 500 known protein kinases in human genome, approximately 60 are members of the RTK family. They are central components of cell signaling networks and play crucial roles in normal physiological processes and disease processes ranging from diabetes to cancer. The MILLIPLEX(R) RTK Phosphoprotein Bead Customizable Panel is used to detect changes in phosphorylated (panTyr) c-Kit, c-Met/HGFR, EGFR, ErbB2/HER2, ErbB3/HER3 , ErbB4/HER4 , FGFR1 , FLT3 , IGF-1R, IR, M-CSFR, PDGFRalpha, PDGFRbeta, TIE1, TIE2, VEGFR1, VEGFR2, and VEGFR3 in cell lysates using the Luminex(R) system. The MILLIPLEX(R) portfolio offers the broadest selection of analytes across a wide range of pathways. Once the panel of interest has been identified, you can rely on the quality we build into each kit to produce results you can trust. Performance criteria evaluated during the validation process include: cross-reactivity, assay CVs, kit stability, and sample behavior. In addition, each kit meets stringent Quality Control criteria to ensure lot-to-lot reproducibility. The MILLIPLEX(R) RTK Phosphoprotein Bead Panel includes: .  Positive and negative control cell lysates provided to qualify assay performance .  Configurable beads to capture analytes of interest .  Optimized detection antibody cocktail designed to yield consistent analyte profiles within a panel Panel Type: Cell Signaling
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA