Mitochondrial Division Inhibitor, mdivi-1 – CAS 338967-87-6 – Calbiochem

Descrição detalhada : A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 M in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50<10 M) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release.
Sinónimos : Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem; Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor, 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one
Fórmula molecula r: C15H10Cl2N2O2S
Armazenamento : -20C
Embalagem : 1X10MG