Monoclonal Anti-AP2 antibody produced in mouse

Descrição detalhada : Monoclonal Anti-AP2 (mouse IgG1 isotype) is derived from the hybridoma A6/2/2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide corresponding to amino acids of human AP2?. In humans and mice, the adaptor protein-2 (AP2) family comprises five different transcription factors namely AP2?, AP2?, AP2 ?, AP2?, and AP2?. These proteins contain N-terminal transactivation domain and C-terminal helix-span-helix motif, which together with a central basic region facilitates dimerization and DNA binding., Adaptor protein-2 (AP2) is a key constituent of clathrin-coated vesicles that mediates the endocytosis of cell membrane components such as G protein-coupled receptors (GPCRs). AP2 is a heterotetramer that consists of ?, ?, ? and ? subunits which bind to tyrosine- and dileucine-based motifs on membrane-associated cargo proteins.
Sinónimos : Anti-AP2TF; Anti-TFAP2
Armazenamento : -20C
Embalagem : 1X100UL