Monoclonal Anti-Calbindin-D-28K antibody produced in mouse

Descrição detalhada : Calbindin-D-28K is a highly conserved 28 kDa calcium binding protein with broad tissue distribution.Monoclonal Anti-Calbindin-D-28K (mouse IgG1 isotype) is derived from the CB-955 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a purified bovine kidney calbindin-D-28K. The isotype is determined by a double diffusion immunoassay using Mouse Monoclonal Antibody Isotyping Reagents, Catalog Number ISO2.Calbindin-D-28K belongs, together with calmodulin, S-100, parvalbumin, troponin C and other proteins, to a family of low molecular weight calcium-binding proteins (CaBPs). These CaBPs have homologous primary structures, which contain polypeptide folds of the EF-hand type for the acceptance of Ca2+. Calbindin is an attractive neuroanatomical marker. Despite its broad tissue distribution, calbindin-D-28K exhibits a cell-type specific expression pattern. Thus, it has been immunocytochemically localized in selected cells in many CNS structures, where it is thought to act either as an intracellular calcium buffer, or in the intramembranous transport of calcium. It is found predominantly in subpopulations of central and peripheral nervous system neurons, and in certain epithelial cells involved in Ca2+ transport such as distal tubular cells and cortical collecting tubules of the kidney, and in enteric neuroendocrine cells. Monoclonal antibody reacting specifically with calbindin-D-28K is instrumental in the localization of calbindin in different tissues and cell populations.
Sinónimos : Calbindin Antibody; Calbindin Antibody - Monoclonal Anti-Calbindin-D-28K antibody produced in mouse
Armazenamento : -20C
Embalagem : 1X100UL