Monoclonal Anti-Carcinoembryonic Antigen antibody produced in mouse

Descrição detalhada : Carcinoembryonic Antigen (CEA) is a member of the immunoglobulin superfamily that regulates cellular signaling and adhesion. CEA inhibits cell differentiation and subsequently facilitates tumor growth . Thus, CEA has been implicated in various cancers, including colorectal, lung and breast tumors Monoclonal Anti-Human Carcinoembryonic Antigen (CEA) reacts specifically with human CEA (CD66e, 180 kDa) from different types of malignant tissues. The antibody detects an epitope which is resistant to 30 minute oxidation by 1% sodium periodate solution in formalin-fixed, paraffin-embedded tissue sections. Enzymatic predigestion with proteolytic enzymes enhances immunohistochemical staining with the antibody.The product reacts with medullary thyroid cancers and also associates with cell surface and cytoplasm of malignant glands in colorectal adenocarcinomas. Additionally, the product reacts weakly with normal colon mucosa and occasionally reacts with bile canalicular and pancreatic acinar cells. However, the antibody does not react with other tested tissue such as term placenta, nor does it bind to non-specific cross-reacting antigen (NCA) in granulocytes., Carcinoembryonic Antigen (CEA) is located on human chromosome 19q13.2.
Sinónimos : CD66e; CEACAM5; Carcinoembryonic antigen-related cell adhesion molecule 5; Cea Antibody; Cea Antibody - Monoclonal Anti-Carcinoembryonic Antigen antibody produced in mouse
Armazenamento : -20C
Embalagem : 1X.2ML