MPP+ iodide

Descrição detalhada : 1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson?s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.
Sinónimos : 1-Methyl-4-phenylpyridinium iodide
Fórmula molecula r: C12H12IN
Armazenamento : Room Temperature
Embalagem : 1X1G