NBD-Binding Peptide II, Cell Permeable, CTP-NBD – Calbiochem

Descrição detalhada : A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50 ~ 50 microM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5 mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Antennapedia fused NBD cell-permeable peptide is also available (>Cat. No. 480025).
Sinónimos : NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem; NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD
Fórmula molecula r: C123H197N47O32
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG