Necrosis Inhibitor, IM-54 – CAS 861891-50-1 – Calbiochem

REF : 480060-5MG
Marca : Sigma-Aldrich
Descrição :Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem The Necrosis Inhibitor, IM-54, also referenced under CAS 861891-50-1, selectively blocks oxidative stress-induced necrotic cell death. This small molecule/inhibitor is primarily used for Cancer applications.
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Descrição detalhada : A cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide- (Cat. No. 341205) induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM., A cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide- (Cat. No. 341205) induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM.
Sinónimos : Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem; 2-(1H-Indol-3-yl)-3-pentylamino-maleimide
Fórmula molecula r: C19H23N3O2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG