NF-kappaB Activation Inhibitor III – CAS 380623-76-7 – Calbiochem

REF : 481411-5MG
Marca : Sigma-Aldrich
Descrição :NF-kappaB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem The NF-kappaB Activation Inhibitor III, also referenced under CAS 380623-76-7, controls the biological activity of NF-kappaB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
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Descrição detalhada : A cell-permeable thiazoloamide compound that inhibits TNF-alpha-stimulated NF-kappaB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-alpha-dependent cell invasion. Does not affect TNF-alpha-induced AP-1 activity. The cellular target appears to be downstream of p38 activation., A cell-permeable inhibitor of TNF-alpha-stimulated NF-kappaB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-alpha-dependent cell invasion. Does not affect TNF-alpha-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
Sinónimos : NF-kappaB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem; 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368
Fórmula molecula r: C10H5ClN4O5S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG