NF-kappaB Activation Inhibitor VII, CID-2858522 – Calbiochem

Descrição detalhada : A cell-permeable selective inhibitor of NF-kappaB activation induced by PKC pathway activators such as PMA (IC50 = 70 nM) in a HEK293 cell-based NF-kappaB luciferase reporter gene assay, by operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways. At 10 µM, this compound only inhibits Raf, TLK1, and JAK2 by 57%, 70%, and 53%, respectively, among a panel of 353 protein kinases. In addition, it attenuates CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T-cells (IC50<5 µM) and anti-IgM-stimulated proliferation of murine B-lymphocytes (IC50 = 2 µM).
Sinónimos : NF-kappaB Activation Inhibitor VII, CID-2858522 - Calbiochem; 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone; CID-2858522; 2-aminobenzimidazole; Compound 1a
Fórmula molecula r: C28H39N3O3
Armazenamento : -20C
Embalagem : 1X10MG