NFAT Activation Inhibitor III – CAS 3519-82-2 – Calbiochem

REF : 480403-5MG
Marca : Sigma-Aldrich
Descrição :NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem The NFAT Activation Inhibitor III, also referenced under CAS 3519-82-2, controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
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Descrição detalhada : A cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 µM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling., A cell-permeable quinone compound that acts as a potent and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT and completely blocks its dephosphorylation, nuclear import of NFAT (~40 µM in C1.7W2 T cells), and induction of cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.
Sinónimos : NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem; Inhibitor of NFAT- Calcineurin Association-6, INCA-6; Inhibitor of NFAT-Calcineurin Association-6, INCA-6
Fórmula molecula r: C20H12O2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG