NovaSyn(R)TGT alcohol resin

Descrição detalhada : NovaSyn TGT alcohol resin is derived from TG amino resin by acylation with Bayer's 4-carboxytrityl linker [1]. Before use the resin must be converted to the chloride form by heating with AcCl [2, 3] or SOCl2 [4, 5] in toluene. The unstable trityl chloride resin should then be used immediately.Attachment of alpha-amino acids is free from enantiomerization, making this support ideal for the immobilization of sensitive residues such as Cys and His.Iodine oxidation of peptides containing Cys(Trt) occurs with release of the peptide from the resin.This support is also ideally suited to the synthesis of prolyl peptides as the bulk of the trityl handle prohibits diketopiperazine formation [6].Cleavage of protected peptide acids from this matrix can be effected by treatment with AcOH/MeOH/DCM [1], 0.5% TFA or HFIP [7].The product number for this product was previously 01-64-0066.To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
Armazenamento : 2-8C
Embalagem : 1X1EA