Nrf2 Activator III, TAT-14 Peptide – Calbiochem

REF : 492042-10MG
Marca : Sigma-Aldrich
Descrição :Nrf2 Activator III, TAT-14 Peptide - Calbiochem The Nrf2 Activator III, TAT-14 Peptide modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Biochemicals applications.
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Descrição detalhada : A 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75 µM). Also shown to suppress LPS-induced TNF-alpha secretion in THP-1 monocytes (~ 37.5 µM).
Sinónimos : Nrf2 Activator III, TAT-14 Peptide - Calbiochem; H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH
Fórmula molecula r: C137H230N48O39
Armazenamento : -20C
Embalagem : 1X10MG