Oxidized ATP (oATP) – CAS 71997-40-5 – Calbiochem

Descrição detalhada : A 2',3'-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2gamma receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
Sinónimos : Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem; Purinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
Fórmula molecula r: C10H14N5O13P3
Armazenamento : -20C
Embalagem : 1X1EA