p21-Activated Kinase Inhibitor III, IPA-3 – CAS 42521-82-4 – Calbiochem

Descrição detalhada : A cell-permeable symmetrical disulfide allosteric inhibitor that selectively targets the autoregulatory domain of group I, but not group II, PAKs (p21-activated kinases) and prevents the activation of PAK1/2/3 (% inhibition= 95, 70, and 60, respectively, with 10 µM inhibitor; IC50 = 2.5 µM for PAK1). Specificity test shows >= 50% inhibition, in the presence of 10 µM ATP and inhibitor, against 9 of 214 non-PAK human kinases. Shown to effectively suppress both basal and PDGF-induced PAK activation at 30 µM in mouse embryonic fibroblasts. IPA-3 does not inhibit the enzymatic activity of preactivated PAKs and reduction of the intramolecular disulfide bond of IPA-3 by DTT renders it inactive.
Sinónimos : p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem; 2,2?-Dihydroxy-1,1?-dinaphthyldisulfide, PAK Inhibitor III
Fórmula molecula r: C20H14O2S2
Armazenamento : -20C
Embalagem : 1X25MG