p38 MAP Kinase Inhibitor III – CAS 581098-48-8 – Calbiochem

Descrição detalhada : A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 380 nM for p38alpha). Shown to effectively suppress LPS-induced cytokine release in vitro (IC50 = 160 nM for TNF-alpha release and 39 nM for IL-1beta release, human PBMC) and in vivo (ED50 = 1.33 mg/kg for TNF-alpha release in mice). Exhibits reduced inhibitory activity against cytochrome P450-2D6 compared to SB 203580 (Cat. No 559389) and is better suited for use in animal models., A cell-permeable methylsulfanylimidazole compound that acts as a potent, selective, reversible, and ATP-competitive p38 MAP kinase inhibitor (IC50 = 0.38 µM for p38alpha). Shown to effectively suppresses LPS-induced cytokine release both in vitro (IC50 = 0.16 and 0.039 µM for TNF-alpha and IL-1beta release, respectively, in human PBMC) and in vivo (ED50 = 1.33 mg/kg for TNF-alpha release in mouse). When compared with SB 203580 (Cat. No. 559389 and 559398), it exhibits reduced inhibitory activity against cytochrome P450-2D6 isoform and, therefore, is better suited for in vivo use. A 10 mM (1 mg/247 µl) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506148) in DMSO is also available.
Sinónimos : p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem; ML3403, (RS)-{4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridin-2-yl}-(1-phenylethyl)amine]
Fórmula molecula r: C23H21FN4S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG