p38 MAP Kinase Inhibitor VIII – CAS 321351-00-2 – Calbiochem

REF : 506163-5MG
Marca : Sigma-Aldrich
Descrição :p38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem The p38 MAP Kinase Inhibitor VIII, also referenced under CAS 321351-00-2, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38alpha and p38beta2 (82% and 93% inhibition with 1 µM inhibitor, respectively; IC50 of p38alpha inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38gamma, p38delta, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC's in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.
Sinónimos : p38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem; (4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone
Fórmula molecula r: C20H16BrClN2O
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG