p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 – Calbiochem

Descrição detalhada : The p75NTR inhibitor Pep5 (Cat. No. 506180) fused to the N-terminal, 11-amino acid protein transduction domain sequence from the HIV TAT protein for membrane permeability. Show to inhibit the association of p75NTR with Rho-GDI in vitro. Reported to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion (DRG) and postnatal cerebellar neurons at a concentration of 100 nM. Reported to be a potential therapeutic agent for the inhibition of regeneration in the central nervous system., The p75NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.
Sinónimos : p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem; TAT-Pep5, H- YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
Fórmula molecula r: C150H227N57O32S2
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X500UG